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What Is Atezolizumab?
Atezolizumab is a monoclonal antibody that affects the actions of the body's immune system. Atezolizumab strengthens your immune system to help your body fight against tumor cells.
Atezolizumab is used to treat a certain type of bladder cancer that has spread to other parts of the body or cannot be removed by surgery.
Atezolizumab is also used to treat non-small cell lung cancer that has spread to other parts of the body.
Atezolizumab is usually given after other cancer medicines have been tried without success.
Atezolizumab may also be used for purposes not listed in this medication guide.
Atezolizumab strengthens your immune system to help your body fight against tumor cells. This may cause the immune system to attack normal healthy tissues or organs. When this happens, you may develop serious or life-threatening medical problems.
Call your doctor at once if you have new or worsening symptoms such as: cough, breathing problems, changes in appetite or weight, diarrhea, stomach pain, vision problems, increased thirst or urination, yellowing of the skin or eyes, mood or behavior changes, severe muscle weakness, or numbness and tingling.
You should not use atezolizumab if you are allergic to it.
To make sure atezolizumab is safe for you, tell your doctor if you have:
- an active infection;
- an immune system disorder such as lupus, ulcerative colitis, or Crohn's disease;
- a history of organ transplant;
- a breathing disorder;
- liver disease; or
- a nervous system disorder such as myasthenia gravis or Guillain Barré syndrome.
Do not use atezolizumab if you are pregnant.It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 5 months after your last dose.
It is not known whether atezolizumab passes into breast milk or if it could harm a nursing baby.You should not breast-feed while using this medicine or within 5 months after your last dose.If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.
Atezolizumab Side Effects
Get emergency medical help if you havesigns of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, light-headed, chilled or feverish, itchy, or have neck pain, back pain, trouble breathing, or swelling in your face.
Call your doctor at once if you have:
- new or worsening cough, chest pain, feeling short of breath;
- diarrhea, bloody or tarry stools;
- nausea or vomiting;
- severe stomach pain (especially in your upper stomach or spreading to your back);
- a light-headed feeling, like you might pass out;
- blurred vision, double vision, eye pain or redness;
- signs of infection--fever, flu symptoms, cough, painful or frequent urination;
- liver problems--loss of appetite, drowsiness, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes);
- nervous system problems--neck stiffness, increased sensitivity to light, confusion, severe muscle weakness, numbness or tingling in your hands or feet; or
- signs of a hormonal disorder--frequent or unusual headaches, feeling light-headed or very tired, mood or behavior changes, hoarse or deepened voice, increased hunger or thirst, increased urination, nausea, vomiting, constipation, hair loss, feeling cold, weight gain, or weight loss.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
- nausea, loss of appetite;
- tiredness; or
- urination problems.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Other drugs may interact with atezolizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Atezolizumab is injected into a vein through an IV. A healthcare provider will give you this injection.
This medicine is given slowly and the IV infusion can take up to 60 minutes to complete.
Atezolizumab is usually given once every 3 weeks until your body no longer responds to the medication.
Atezolizumab can increase your risk of infection by changing the way your immune system works.You will need frequent medical tests.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Call your doctor for instructions if you miss an appointment for your atezolizumab injection.
Copyright 1996-2019 Cerner Multum, Inc.
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